Multi-objective optimization reveals time- and dose-dependent inflammatory cytokine-mediated regulation of human stem cell derived T-cell development

The generation of T-cells from stem cells in vitro could provide an alternative source of cells for immunotherapies. T-cell development from hematopoietic stem and progenitor cells (HSPCs) is tightly regulated through Notch pathway activation by Delta-like (DL) ligands 1 and 4. Other molecules, such...

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Detalles Bibliográficos
Autores principales: Edgar, John M., Michaels, Yale S., Zandstra, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795204/
https://www.ncbi.nlm.nih.gov/pubmed/35087040
http://dx.doi.org/10.1038/s41536-022-00210-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795204/
https://www.ncbi.nlm.nih.gov/pubmed/35087040
http://dx.doi.org/10.1038/s41536-022-00210-1

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