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Intranasal calcitonin gene-related peptide administration impairs fear memory retention in mice through the PKD/p-HDAC5/Npas4 pathway

The calcitonin gene-related peptide (CGRP) suppresses fear memory retention in mice. Although intracerebroventricular administration of CGRP alters the fear memory processes, making it a promising therapeutic strategy for post-traumatic stress disorder (PTSD), direct brain injection into patients is...

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Detalles Bibliográficos
Autores principales: Hashikawa-Hobara, Narumi, Yoneyama, Yoshikazu, Fujiwara, Kyoushiro, Hashikawa, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795377/
https://www.ncbi.nlm.nih.gov/pubmed/35087146
http://dx.doi.org/10.1038/s41598-022-05518-y