Long-term oral administration of an HNF4α agonist prevents weight gain and hepatic steatosis by promoting increased mitochondrial mass and function

We report here that the potent HNF4α agonist N-trans-caffeoyltyramine (NCT) promotes weight loss by inducing an increase in mitochondrial mass and function, including fatty acid oxidation. Previously, we found in a short term trial in obese mice that NCT promoted reversal of hepatic steatosis throug...

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Detalles Bibliográficos
Autores principales: Veeriah, Vimal, Lee, Seung-Hee, Levine, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795379/
https://www.ncbi.nlm.nih.gov/pubmed/35087037
http://dx.doi.org/10.1038/s41419-022-04521-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795379/
https://www.ncbi.nlm.nih.gov/pubmed/35087037
http://dx.doi.org/10.1038/s41419-022-04521-5

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