Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B

Glycosyltransferases typically display acceptor substrate flexibility but more stringent donor specificity. BsGT-1 is a highly effective glycosyltransferase to glycosylate macrolides, including epothilones, promising antitumor compounds. Here, we show that BsGT-1 has three major regions significantl...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Peng, Zhang, Lijuan, Jiang, Xukai, Diao, Xiao-tong, Li, Shuang, Li, Dan-dan, Zhang, Zheng, Fang, Junqiang, Tang, Ya-jie, Wu, Da-lei, Wu, Changsheng, Li, Yue-zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795383/
https://www.ncbi.nlm.nih.gov/pubmed/35087210
http://dx.doi.org/10.1038/s42003-022-03047-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795383/
https://www.ncbi.nlm.nih.gov/pubmed/35087210
http://dx.doi.org/10.1038/s42003-022-03047-y

Ejemplares similares