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Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B

Glycosyltransferases typically display acceptor substrate flexibility but more stringent donor specificity. BsGT-1 is a highly effective glycosyltransferase to glycosylate macrolides, including epothilones, promising antitumor compounds. Here, we show that BsGT-1 has three major regions significantl...

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Detalles Bibliográficos
Autores principales:	Zhang, Peng, Zhang, Lijuan, Jiang, Xukai, Diao, Xiao-tong, Li, Shuang, Li, Dan-dan, Zhang, Zheng, Fang, Junqiang, Tang, Ya-jie, Wu, Da-lei, Wu, Changsheng, Li, Yue-zhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795383/ https://www.ncbi.nlm.nih.gov/pubmed/35087210 http://dx.doi.org/10.1038/s42003-022-03047-y

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