Differential toxicity to murine small and large intestinal epithelium induced by oncology drugs

Gastrointestinal toxicity is a major concern in the development of drugs. Here, we establish the ability to use murine small and large intestine-derived monolayers to screen drugs for toxicity. As a proof-of-concept, we applied this system to assess gastrointestinal toxicity of ~50 clinically used o...

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Detalles Bibliográficos
Autores principales: Bieber, Jake M., Sanman, Laura E., Sun, Xiaoxiao, Hammerlindl, Heinz, Bao, Feng, Roth, Maike A., Koleske, Megan L., Huang, Liusheng, Aweeka, Fran, Wu, Lani F., Altschuler, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795448/
https://www.ncbi.nlm.nih.gov/pubmed/35087225
http://dx.doi.org/10.1038/s42003-022-03048-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795448/
https://www.ncbi.nlm.nih.gov/pubmed/35087225
http://dx.doi.org/10.1038/s42003-022-03048-x

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