Therapeutic enzyme engineering using a generative neural network

Enhancing the potency of mRNA therapeutics is an important objective for treating rare diseases, since it may enable lower and less-frequent dosing. Enzyme engineering can increase potency of mRNA therapeutics by improving the expression, half-life, and catalytic efficiency of the mRNA-encoded enzym...

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Detalles Bibliográficos
Autores principales: Giessel, Andrew, Dousis, Athanasios, Ravichandran, Kanchana, Smith, Kevin, Sur, Sreyoshi, McFadyen, Iain, Zheng, Wei, Licht, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795449/
https://www.ncbi.nlm.nih.gov/pubmed/35087131
http://dx.doi.org/10.1038/s41598-022-05195-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795449/
https://www.ncbi.nlm.nih.gov/pubmed/35087131
http://dx.doi.org/10.1038/s41598-022-05195-x

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