Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers

Topoisomerases nick and reseal DNA to relieve torsional stress associated with transcription and replication and to resolve structures such as knots and catenanes. Stabilization of the yeast Top2 cleavage intermediates is mutagenic in yeast, but whether this extends to higher eukaryotes is less clea...

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Detalles Bibliográficos
Autores principales: Boot, Arnoud, Liu, Mo, Stantial, Nicole, Shah, Viraj, Yu, Willie, Nitiss, Karin C., Nitiss, John L., Jinks-Robertson, Sue, Rozen, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795545/
https://www.ncbi.nlm.nih.gov/pubmed/35058360
http://dx.doi.org/10.1073/pnas.2114024119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795545/
https://www.ncbi.nlm.nih.gov/pubmed/35058360
http://dx.doi.org/10.1073/pnas.2114024119

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