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Recurrent mutations in topoisomerase IIα cause a previously undescribed mutator phenotype in human cancers
Topoisomerases nick and reseal DNA to relieve torsional stress associated with transcription and replication and to resolve structures such as knots and catenanes. Stabilization of the yeast Top2 cleavage intermediates is mutagenic in yeast, but whether this extends to higher eukaryotes is less clea...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795545/ https://www.ncbi.nlm.nih.gov/pubmed/35058360 http://dx.doi.org/10.1073/pnas.2114024119 |