NO rapidly mobilizes cellular heme to trigger assembly of its own receptor

Nitric oxide (NO) signaling in biology relies on its activating cyclic guanosine monophosphate (cGMP) production by the NO receptor soluble guanylyl cyclase (sGC). sGC must obtain heme and form a heterodimer to become functional, but paradoxically often exists as an immature heme-free form in cells...

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Detalles Bibliográficos
Autores principales: Dai, Yue, Faul, Emily M., Ghosh, Arnab, Stuehr, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795550/
https://www.ncbi.nlm.nih.gov/pubmed/35046034
http://dx.doi.org/10.1073/pnas.2115774119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795550/
https://www.ncbi.nlm.nih.gov/pubmed/35046034
http://dx.doi.org/10.1073/pnas.2115774119

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