XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is associated with extensive dysregulation of the epigenome and epigenetic regulators, such as bromodomain and extraterminal motif (BET) proteins, have been suggested as potential targets for therapy. However, single-agent BET inhibition has shown poor efficac...

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Detalles Bibliográficos
Autores principales: Principe, Daniel R., Xiong, Rui, Li, Yangfeng, Pham, Thao N. D., Kamath, Suneel D., Dubrovskyi, Oleksii, Ratia, Kiira, Huang, Fei, Zhao, Jiong, Shen, Zhengnan, Thummuri, Dinesh, Daohong, Zhou, Underwood, Patrick W., Trevino, Jose, Munshi, Hidayatullah G., Thatcher, Gregory R. J., Rana, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795568/
https://www.ncbi.nlm.nih.gov/pubmed/35064087
http://dx.doi.org/10.1073/pnas.2116764119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795568/
https://www.ncbi.nlm.nih.gov/pubmed/35064087
http://dx.doi.org/10.1073/pnas.2116764119

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