Cargando…
The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel Na(V)1.8 to Enhance Activation
Venoms from cone snails and arachnids are a rich source of peptide modulators of voltage-gated sodium (Na(V)) channels, however relatively few venom-derived peptides with activity at the mammalian Na(V)1.8 subtype have been isolated. Here, we describe the discovery and functional characterisation of...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795738/ https://www.ncbi.nlm.nih.gov/pubmed/35095499 http://dx.doi.org/10.3389/fphar.2021.789570 |