Cargando…

The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel Na(V)1.8 to Enhance Activation

Venoms from cone snails and arachnids are a rich source of peptide modulators of voltage-gated sodium (Na(V)) channels, however relatively few venom-derived peptides with activity at the mammalian Na(V)1.8 subtype have been isolated. Here, we describe the discovery and functional characterisation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Deuis, Jennifer R., Ragnarsson, Lotten, Robinson, Samuel D., Dekan, Zoltan, Chan, Lerena, Jin, Ai-Hua, Tran, Poanna, McMahon, Kirsten L., Li, Shengnan, Wood, John N., Cox, James J., King, Glenn F., Herzig, Volker, Vetter, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795738/
https://www.ncbi.nlm.nih.gov/pubmed/35095499
http://dx.doi.org/10.3389/fphar.2021.789570