The Effects of Combined Therapy With Metformin and Hydroxypropyl-β-Cyclodextrin in a Mouse Model of Niemann-Pick Disease Type C1

Niemann–Pick disease type C1 (NPC1) is a neurodegenerative disorder characterized by lysosomal storage of free cholesterol. 2-Hydroxypropyl-β-cyclodextrin (HPβCD) is a cyclic oligosaccharide derivative that is being developed to treat NPC1. Recently, metformin was reported to be beneficial in variou...

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Detalles Bibliográficos
Autores principales: Du, Jiang, Liu, Xinlei, Zhang, Yan, Han, Xiaojing, Ma, Chunya, Liu, Yanli, Guan, Lihong, Qiao, Liang, Lin, Juntang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795875/
https://www.ncbi.nlm.nih.gov/pubmed/35095535
http://dx.doi.org/10.3389/fphar.2021.825425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795875/
https://www.ncbi.nlm.nih.gov/pubmed/35095535
http://dx.doi.org/10.3389/fphar.2021.825425

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