A New Organocatalytic Desymmetrization Reaction Enables the Enantioselective Total Synthesis of Madangamine E

[Image: see text] The enantioselective total synthesis of madangamine E has been completed in 30 steps, enabled by a new catalytic and highly enantioselective desymmetrizing intramolecular Michael addition reaction of a prochiral ketone to a tethered β,β′-disubstituted nitroolefin. This key carbon–c...

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Detalles Bibliográficos
Autores principales: Shiomi, Shinya, Shennan, Benjamin D. A., Yamazaki, Ken, Fuentes de Arriba, Ángel L., Vasu, Dhananjayan, Hamlin, Trevor A., Dixon, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796237/
https://www.ncbi.nlm.nih.gov/pubmed/35037758
http://dx.doi.org/10.1021/jacs.1c12040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796237/
https://www.ncbi.nlm.nih.gov/pubmed/35037758
http://dx.doi.org/10.1021/jacs.1c12040

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