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Plasma protein binding prediction focusing on residue-level features and circularity of cyclic peptides by deep learning
MOTIVATION: In recent years, cyclic peptide drugs have been receiving increasing attention because they can target proteins that are difficult to be tackled by conventional small-molecule drugs or antibody drugs. Plasma protein binding rate ([Formula: see text]) is a significant pharmacokinetic prop...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796384/ https://www.ncbi.nlm.nih.gov/pubmed/34849593 http://dx.doi.org/10.1093/bioinformatics/btab726 |