The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation

The first intracellular loop (ICL1) of G protein-coupled receptors (GPCRs) has received little attention, although there is evidence that, with the 8(th) helix (H8), it is involved in early conformational changes following receptor activation as well as contacting the G protein β subunit. In class B...

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Detalles Bibliográficos
Autores principales: Winfield, Ian, Barkan, Kerry, Routledge, Sarah, Robertson, Nathan J., Harris, Matthew, Jazayeri, Ali, Simms, John, Reynolds, Christopher A., Poyner, David R., Ladds, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796428/
https://www.ncbi.nlm.nih.gov/pubmed/35095763
http://dx.doi.org/10.3389/fendo.2021.792912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796428/
https://www.ncbi.nlm.nih.gov/pubmed/35095763
http://dx.doi.org/10.3389/fendo.2021.792912

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