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The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation
The first intracellular loop (ICL1) of G protein-coupled receptors (GPCRs) has received little attention, although there is evidence that, with the 8(th) helix (H8), it is involved in early conformational changes following receptor activation as well as contacting the G protein β subunit. In class B...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796428/ https://www.ncbi.nlm.nih.gov/pubmed/35095763 http://dx.doi.org/10.3389/fendo.2021.792912 |