Cargando…

Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology

BACKGROUND: Intrathecal drug delivery has a significant role in pain management and central nervous system (CNS) disease therapeutics. A fluid-physics based tool to assist clinicians in choosing specific drug doses to the spine or brain may help improve treatment schedules. METHODS: This study appli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khani, Mohammadreza, Burla, Goutham Kumar Reddy, Sass, Lucas R., Arters, Ostin N., Xing, Tao, Wu, Haiming, Martin, Bryn A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796513/ https://www.ncbi.nlm.nih.gov/pubmed/35090516 http://dx.doi.org/10.1186/s12987-022-00304-4

Ejemplares similares

Investigation of Human Intrathecal Solute Transport Dynamics Using a Novel in vitro Cerebrospinal Fluid System Analog
por: Seiner, Akari, et al.
Publicado: (2022)

In vitro and numerical simulation of blood removal from cerebrospinal fluid: comparison of lumbar drain to Neurapheresis therapy
por: Khani, Mohammadreza, et al.
Publicado: (2020)

Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients
por: Sass, Lucas R., et al.
Publicado: (2020)

Characterization of intrathecal cerebrospinal fluid geometry and dynamics in cynomolgus monkeys (macaca fascicularis) by magnetic resonance imaging
por: Khani, Mohammadreza, et al.
Publicado: (2019)

Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection
por: Raghunandan, Aditya, et al.
Publicado: (2021)

Intrathecal catheter implantation decreases cerebrospinal fluid dynamics in cynomolgus monkeys
por: Khani, Mohammadreza, et al.
Publicado: (2020)

Primary spontaneous cerebrospinal fluid leaks located at the clivus
por: Van Zele, Thibaut, et al.
Publicado: (2013)

The physiology and pathophysiology of cerebrospinal fluid: new evidence
por: Klarica, Marijan, et al.
Publicado: (2021)

THE DISTRIBUTION WITHIN THE BRAIN OF FERRITIN INJECTED INTO CEREBROSPINAL FLUID COMPARTMENTS : I. Ependymal Distribution
por: Brightman, Milton W.
Publicado: (1965)

Cerebrospinal fluid infection after lumbar nerve root steroid injection: a case report
por: Kim, Kwan-Sub, et al.
Publicado: (2017)

Epidural Fibrin Sealant Injection for the Management of Cerebrospinal Fluid Leak Following Dural Puncture in Children
por: Armstrong, Stephanie A, et al.
Publicado: (2020)

Cerebrospinal Fluid
por: Bailey, Cleta Sue, et al.
Publicado: (1997)

Cerebrospinal Fluid
por: Vernau, William, et al.
Publicado: (2008)

Cerebrospinal fluid physiology: visualization of cerebrospinal fluid dynamics using the magnetic resonance imaging Time-Spatial Inversion Pulse method
por: Yamada, Shinya
Publicado: (2014)

A Minimally-Invasive Method for Serial Cerebrospinal Fluid Collection and Injection in Rodents with High Survival Rates
por: Han, Jingrong Regina, et al.
Publicado: (2023)

Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus
por: Owler, Brian K, et al.
Publicado: (2010)

The cerebrospinal fluid in retinoblastoma.
por: Ifekwunigwe, A. E., et al.
Publicado: (1966)

THE CEREBROSPINAL FLUID IN SYPHILIS
por: Ellis, Arthur W. M., et al.
Publicado: (1913)

Cerebrospinal fluid rhinorrhea
por: Mohanty, Aaron
Publicado: (2016)

Cerebrospinal fluid dynamics
Publicado: (2021)

The Comparison of Plasma and Cerebrospinal Fluid R(−)- and S(+)-Flurbiprofen Concentration After Intravenous Injection of Flurbiprofen Axetil in Human Subjects
por: Yao, Han, et al.
Publicado: (2021)

Research into the Physiology of Cerebrospinal Fluid Reaches a New Horizon: Intimate Exchange between Cerebrospinal Fluid and Interstitial Fluid May Contribute to Maintenance of Homeostasis in the Central Nervous System
por: MATSUMAE, Mitsunori, et al.
Publicado: (2016)

Intravenous Injection of Choleraic and Other Organic Fluids
Publicado: (1875)

Treatment of Eclampsia by Intercellular Injection of Saline Fluid
por: Jardine, Robert
Publicado: (1899)

The Intra-Vascular Injection of Blood and Other Fluids
por: Hutchison, Joseph C.
Publicado: (1885)

Fluid dynamics of cerebrospinal fluid flow in perivascular spaces
por: Thomas, John H.
Publicado: (2019)

Computational fluid dynamics model to predict the dynamical behavior of the cerebrospinal fluid through implementation of physiological boundary conditions
por: Vandenbulcke, Sarah, et al.
Publicado: (2022)

Commentary: Unnecessary preoperative epidural steroid injections lead to cerebrospinal fluid leaks confirmed during spinal stenosis surgery
por: Epstein, Nancy E.
Publicado: (2014)

Levobupivacaine for Spinal Anesthesia in Children: Cerebrospinal Fluid Aspiration Before the Injection Does not Affect the Spread or Duration of the Sensory Block
por: Kokki, Merja, et al.
Publicado: (2016)

An inadvertent subarachnoid injection reversed by cerebrospinal fluid lavage for the treatment of chronic low back pain: A case report
por: Sun, Xiaodi, et al.
Publicado: (2019)

Pharmacokinetics and antiviral activity of cabotegravir and rilpivirine in cerebrospinal fluid following long-acting injectable administration in HIV-infected adults
por: Letendre, Scott L, et al.
Publicado: (2020)

Cerebrospinal fluid cytology : an introduction and atlas
por: Oehmichen, Manfred
Publicado: (1976)

Bromocriptine or cabergoline-induced cerebrospinal fluid rhinorrhea: A life-threatening complication during management of prolactinoma
por: Singh, Pratibha, et al.
Publicado: (2011)

Cerebrospinal fluid in multiple sclerosis
por: Rammohan, Kottil W.
Publicado: (2009)

Borrelia valaisiana in Cerebrospinal Fluid
por: Diza, Eudoxia, et al.
Publicado: (2004)

Cerebrospinal fluid sodium rhythms
por: Harrington, Michael G, et al.
Publicado: (2010)

Imhotep and the Discovery of Cerebrospinal Fluid
por: Blomstedt, Patric
Publicado: (2014)

Enigma of cerebrospinal fluid dynamics
por: Klarica, Marijan, et al.
Publicado: (2014)

Cerebrospinal Fluid Pressure and Glaucoma
por: Jonas, Jost B., et al.
Publicado: (2013)

The Maze of the Cerebrospinal Fluid Discovery
por: Herbowski, Leszek
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_6v3lc1vg0fkd8thki8aj3kp7h3