Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve

Calcific aortic valve disease (CAVD) is characterized by a fibrocalcific process. The regulatory mechanisms that drive the fibrotic response in the aortic valve (AV) are poorly understood. Long noncoding RNAs derived from super-enhancers (lncRNA-SE) control gene expression and cell fate. Herein, mul...

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Detalles Bibliográficos
Autores principales: Chignon, Arnaud, Argaud, Déborah, Boulanger, Marie-Chloé, Mkannez, Ghada, Bon-Baret, Valentin, Li, Zhonglin, Thériault, Sébastien, Bossé, Yohan, Mathieu, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797204/
https://www.ncbi.nlm.nih.gov/pubmed/35041643
http://dx.doi.org/10.1371/journal.pgen.1010010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797204/
https://www.ncbi.nlm.nih.gov/pubmed/35041643
http://dx.doi.org/10.1371/journal.pgen.1010010

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