Sentinel lymph node biopsy in endometrial cancer: state of the art

Endometrial cancer (EC) is the most common gynecological neoplasm in developed countries. In literature, there are discordant data regarding the therapeutic value of systematic lymphadenectomy whereas the importance of lymph node status for determining prognosis and the need for adjuvant treatment i...

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Autores principales: Della Corte, Luigi, Giampaolino, Pierluigi, Mercorio, Antonio, Riemma, Gaetano, Schiattarella, Antonio, De Franciscis, Pasquale, Bifulco, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797296/
https://www.ncbi.nlm.nih.gov/pubmed/35117375
http://dx.doi.org/10.21037/tcr.2020.04.21
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author Della Corte, Luigi
Giampaolino, Pierluigi
Mercorio, Antonio
Riemma, Gaetano
Schiattarella, Antonio
De Franciscis, Pasquale
Bifulco, Giuseppe
author_facet Della Corte, Luigi
Giampaolino, Pierluigi
Mercorio, Antonio
Riemma, Gaetano
Schiattarella, Antonio
De Franciscis, Pasquale
Bifulco, Giuseppe
author_sort Della Corte, Luigi
collection PubMed
description Endometrial cancer (EC) is the most common gynecological neoplasm in developed countries. In literature, there are discordant data regarding the therapeutic value of systematic lymphadenectomy whereas the importance of lymph node status for determining prognosis and the need for adjuvant treatment is undoubted. Given the low risk of lymph-node metastases in the apparent early-stage disease and the significant surgical and postoperative risks when performing a complete pelvic lymphadenectomy, the surgical approach in these patients is controversial, ranging from no nodal evaluation to comprehensive pelvic and aortic lymphadenectomy. The recent introduction of sentinel node mapping represents the mid-way between the execution and omission of node dissection in EC patients. Indeed, the sentinel node mapping has rapidly emerged as an alternative to complete lymphadenectomy to reduce morbidity. In the present review, we discuss the role of sentinel node mapping in the surgical management of EC evaluating all aspects of this procedure.
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spelling pubmed-87972962022-02-02 Sentinel lymph node biopsy in endometrial cancer: state of the art Della Corte, Luigi Giampaolino, Pierluigi Mercorio, Antonio Riemma, Gaetano Schiattarella, Antonio De Franciscis, Pasquale Bifulco, Giuseppe Transl Cancer Res Review Article on Endometrial Cancer Endometrial cancer (EC) is the most common gynecological neoplasm in developed countries. In literature, there are discordant data regarding the therapeutic value of systematic lymphadenectomy whereas the importance of lymph node status for determining prognosis and the need for adjuvant treatment is undoubted. Given the low risk of lymph-node metastases in the apparent early-stage disease and the significant surgical and postoperative risks when performing a complete pelvic lymphadenectomy, the surgical approach in these patients is controversial, ranging from no nodal evaluation to comprehensive pelvic and aortic lymphadenectomy. The recent introduction of sentinel node mapping represents the mid-way between the execution and omission of node dissection in EC patients. Indeed, the sentinel node mapping has rapidly emerged as an alternative to complete lymphadenectomy to reduce morbidity. In the present review, we discuss the role of sentinel node mapping in the surgical management of EC evaluating all aspects of this procedure. AME Publishing Company 2020-12 /pmc/articles/PMC8797296/ /pubmed/35117375 http://dx.doi.org/10.21037/tcr.2020.04.21 Text en 2020 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Review Article on Endometrial Cancer
Della Corte, Luigi
Giampaolino, Pierluigi
Mercorio, Antonio
Riemma, Gaetano
Schiattarella, Antonio
De Franciscis, Pasquale
Bifulco, Giuseppe
Sentinel lymph node biopsy in endometrial cancer: state of the art
title Sentinel lymph node biopsy in endometrial cancer: state of the art
title_full Sentinel lymph node biopsy in endometrial cancer: state of the art
title_fullStr Sentinel lymph node biopsy in endometrial cancer: state of the art
title_full_unstemmed Sentinel lymph node biopsy in endometrial cancer: state of the art
title_short Sentinel lymph node biopsy in endometrial cancer: state of the art
title_sort sentinel lymph node biopsy in endometrial cancer: state of the art
topic Review Article on Endometrial Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797296/
https://www.ncbi.nlm.nih.gov/pubmed/35117375
http://dx.doi.org/10.21037/tcr.2020.04.21
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