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The influence of tumor heterogeneity on sensitivity of EGFR-mutant lung adenocarcinoma cells to EGFR-TKIs

BACKGROUND: Studies have shown that extensive genetic or spatial heterogeneity is present within tumors. The present study explored the influence of heterogeneous cells in the tumor microenvironment (TME) on the sensitivity of EGFR-mutant lung adenocarcinoma cells to EGFR-TKIs and further investigat...

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Detalles Bibliográficos
Autores principales: Sun, Li, Li, Yao-Yong, Ma, Jie-Tao, Zhang, Shu-Ling, Huang, Le-Tian, Han, Cheng-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797522/
https://www.ncbi.nlm.nih.gov/pubmed/35116934
http://dx.doi.org/10.21037/tcr.2019.09.01