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Human cancer cells compensate the genes unfavorable for translation by N(6)-methyladenosine modification and enhance their translation efficiency

BACKGROUND: N(6)-methyladenosine (m(6)A) is the methylation of RNA adenosines that participates in multiple biological processes, such as facilitating translation of host genes via the reader protein YTHDF1. The core writer protein of m(6)A in humans is METTL3. METHODS: We utilized YTHDF1 target gen...

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Detalles Bibliográficos
Autores principales: Chu, Duan, Wei, Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797713/
https://www.ncbi.nlm.nih.gov/pubmed/35116782
http://dx.doi.org/10.21037/tcr.2019.03.04