Akt/mTOR and AMPK signaling pathways are responsible for liver X receptor agonist GW3965-enhanced gefitinib sensitivity in non-small cell lung cancer cell lines

BACKGROUND: This study was to systemically analyze the mechanism of LXR ligand GW3965-induced sensitivity to EGFR-TKI in EGFR-TKI-resistant non-small cell lung cancer (NSCLC) cell lines. METHODS: Gefitinib-resistant PC9 cell line (EGFR exon 19 deletion) was treated with single and combined treatment...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qingbo, Shen, Bo, Qin, Xiaobing, Liu, Siwen, Feng, Jifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797756/
https://www.ncbi.nlm.nih.gov/pubmed/35116735
http://dx.doi.org/10.21037/tcr.2018.12.34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797756/
https://www.ncbi.nlm.nih.gov/pubmed/35116735
http://dx.doi.org/10.21037/tcr.2018.12.34

Ejemplares similares