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Akt/mTOR and AMPK signaling pathways are responsible for liver X receptor agonist GW3965-enhanced gefitinib sensitivity in non-small cell lung cancer cell lines
BACKGROUND: This study was to systemically analyze the mechanism of LXR ligand GW3965-induced sensitivity to EGFR-TKI in EGFR-TKI-resistant non-small cell lung cancer (NSCLC) cell lines. METHODS: Gefitinib-resistant PC9 cell line (EGFR exon 19 deletion) was treated with single and combined treatment...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
AME Publishing Company
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797756/ https://www.ncbi.nlm.nih.gov/pubmed/35116735 http://dx.doi.org/10.21037/tcr.2018.12.34 |