Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor

c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCF(Fbw7) ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron centered at threonine 58 (T58), and mutations of Fbw7 or T58 impair Myc degradation in cancers. Here, we identify a second F...

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Detalles Bibliográficos
Autores principales: Welcker, Markus, Wang, Baiyun, Rusnac, Domniţa-Valeria, Hussaini, Yasser, Swanger, Jherek, Zheng, Ning, Clurman, Bruce E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797792/
https://www.ncbi.nlm.nih.gov/pubmed/35089787
http://dx.doi.org/10.1126/sciadv.abl7872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797792/
https://www.ncbi.nlm.nih.gov/pubmed/35089787
http://dx.doi.org/10.1126/sciadv.abl7872

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