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Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor

c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCF(Fbw7) ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron centered at threonine 58 (T58), and mutations of Fbw7 or T58 impair Myc degradation in cancers. Here, we identify a second F...

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Detalles Bibliográficos
Autores principales:	Welcker, Markus, Wang, Baiyun, Rusnac, Domniţa-Valeria, Hussaini, Yasser, Swanger, Jherek, Zheng, Ning, Clurman, Bruce E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797792/ https://www.ncbi.nlm.nih.gov/pubmed/35089787 http://dx.doi.org/10.1126/sciadv.abl7872

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