Tumor necrosis factor-α promotes airway mucus hypersecretion by repressing miR-146a-5p and miR-134-5p levels in human airway epithelial cells

BACKGROUND: Airway mucus acts as an indispensable protective component of innate immune response against invading pathogens. However, airway mucus hypersecretion, largely consisting of mucin 5AC (MUC5AC), is the leading cause of airflow obstruction and airway hyperresponsiveness that contributes to...

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Detalles Bibliográficos
Autores principales: Fu, Hui-Ting, Zhang, Yan, Zhang, Ping, Wu, Huan, Sun, Xuan-Qiu, Shen, Shu-Yang, Dou, Dan-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797934/
https://www.ncbi.nlm.nih.gov/pubmed/35116702
http://dx.doi.org/10.21037/tcr-20-3375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797934/
https://www.ncbi.nlm.nih.gov/pubmed/35116702
http://dx.doi.org/10.21037/tcr-20-3375

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