Cargando…

Acid-induced autophagy protects human gastric cancer cells from apoptosis by activating Erk1/2 pathway

BACKGROUND: Acidic microenvironments exist widely in tumors. However, the specific mechanism of cancer cell survival under an acidic microenvironment remains unknown. This study aims to investigate whether acid can induce autophagy and examine the mechanism of autophagy in gastric cancer cells. METH...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Yuan, Qi, Weiwei, Liu, Shihai, Zhao, Shufen, Lv, Jing, Qiu, Wensheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798117/ https://www.ncbi.nlm.nih.gov/pubmed/35116899 http://dx.doi.org/10.21037/tcr.2019.07.42

Ejemplares similares

E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer
por: Li, Hui, et al.
Publicado: (2021)

Inhibiting Forkhead box K1 induces autophagy to reverse epithelial-mesenchymal transition and metastasis in gastric cancer by regulating Myc-associated zinc finger protein in an acidic microenvironment
por: Wang, Yixuan, et al.
Publicado: (2020)

TSPAN9 suppresses the chemosensitivity of gastric cancer to 5-fluorouracil by promoting autophagy
por: Qi, Yaoyue, et al.
Publicado: (2020)

Tetraspanin family identified as the central genes detected in gastric cancer using bioinformatics analysis
por: Qi, Weiwei, et al.
Publicado: (2018)

TSPAN9 and EMILIN1 synergistically inhibit the migration and invasion of gastric cancer cells by increasing TSPAN9 expression
por: Qi, Yaoyue, et al.
Publicado: (2019)

Mitochondrial ROS activates ERK/autophagy pathway as a protected mechanism against deoxypodophyllotoxin-induced apoptosis
por: Kim, Sang-Hun, et al.
Publicado: (2017)

Nestin is essential for cellular redox homeostasis and gastric cancer metastasis through the mediation of the Keap1–Nrf2 axis
por: Lv, Jing, et al.
Publicado: (2021)

Usnic Acid Induces Cycle Arrest, Apoptosis, and Autophagy in Gastric Cancer Cells In Vitro and In Vivo
por: Geng, Xiaoge, et al.
Publicado: (2018)

FOXM1 mediates resistance to docetaxel in gastric cancer via up-regulating Stathmin
por: Li, Xiaoxiao, et al.
Publicado: (2014)

Identification and Validation of SNP-Containing Genes With Prognostic Value in Gastric Cancer via Integrated Bioinformatics Analysis
por: Li, Hui, et al.
Publicado: (2021)

Protective autophagy antagonizes oxaliplatin-induced apoptosis in gastric cancer cells
por: Xu, Ling, et al.
Publicado: (2011)

Involvement of the ERK pathway in the protective effects of glycyrrhizic acid against the MPP(+)-induced apoptosis of dopaminergic neuronal cells
por: TENG, LESHENG, et al.
Publicado: (2014)

Acidic stress induces protective autophagy in SGC7901 cells
por: Sheng, Jie, et al.
Publicado: (2018)

Stigmasterol Simultaneously Induces Apoptosis and Protective Autophagy by Inhibiting Akt/mTOR Pathway in Gastric Cancer Cells
por: Zhao, Huange, et al.
Publicado: (2021)

Vortioxetine induces apoptosis and autophagy of gastric cancer AGS cells via the PI3K/AKT pathway
por: Lv, Gao‐Bo, et al.
Publicado: (2020)

Reduction of apoptosis by proanthocyanidin-induced autophagy in the human gastric cancer cell line MGC-803
por: NIE, CHAO, et al.
Publicado: (2016)

The worthy role of hepatic arterial infusion chemotherapy in combination with anti-programmed cell death protein 1 monoclonal antibody immunotherapy in advanced hepatocellular carcinoma
por: Ding, Yixin, et al.
Publicado: (2023)

Immune checkpoint inhibitor combination therapy for gastric cancer: Research progress
por: Song, Xiaoxu, et al.
Publicado: (2020)

P27 Protects Cardiomyocytes from Sepsis via Activation of Autophagy and Inhibition of Apoptosis
por: Zhao, Xianyuan, et al.
Publicado: (2018)

Piperlongumine induces apoptosis via the MAPK pathway and ERK-mediated autophagy in human melanoma cells
por: Jeon, Su-Ji, et al.
Publicado: (2023)

Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways
por: JIN, XIAOHONG, et al.
Publicado: (2016)

Aristolochic Acid I Induced Autophagy Extenuates Cell Apoptosis via ERK 1/2 Pathway in Renal Tubular Epithelial Cells
por: Zeng, Youjia, et al.
Publicado: (2012)

Scutellarin induces apoptosis and autophagy in NSCLC cells through ERK1/2 and AKT Signaling Pathways in vitro and in vivo
por: Sun, ChaoYue, et al.
Publicado: (2018)

Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy
por: Li, Xiaodong, et al.
Publicado: (2017)

Expression and function of transmembrane 4 superfamily proteins in digestive system cancers
por: Qi, Yaoyue, et al.
Publicado: (2020)

The protective effect of gentisic acid on rheumatoid arthritis via the RAF/ERK signaling pathway
por: Dong, Xiaojun, et al.
Publicado: (2022)

β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis
por: Liu, Jing, et al.
Publicado: (2011)

Knockdown of TRIM37 Promotes Apoptosis and Suppresses Tumor Growth in Gastric Cancer by Inactivation of the ERK1/2 Pathway
por: Zhu, Hongyi, et al.
Publicado: (2020)

Shengma Biejia Decoction Inhibits Cell Growth in Multiple Myeloma by Inducing Autophagy-Mediated Apoptosis Through the ERK/mTOR Pathway
por: Dai, Huibo, et al.
Publicado: (2021)

7-Epitaxol Induces Apoptosis and Autophagy in Head and Neck Squamous Cell Carcinoma through Inhibition of the ERK Pathway
por: Kumar, V. Bharath, et al.
Publicado: (2021)

Autophagy protects against palmitate-induced apoptosis in hepatocytes
por: Cai, Ning, et al.
Publicado: (2014)

Autophagy Protects against Palmitic Acid-Induced Apoptosis in Podocytes in vitro
por: Jiang, Xu-shun, et al.
Publicado: (2017)

Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosis
por: Wang, Huan, et al.
Publicado: (2021)

Netrin‐1 regulates ERK1/2 signaling pathway and autophagy activation in wear particle‐induced osteoclastogenesis
por: Wang, Lei, et al.
Publicado: (2021)

Ferroptosis‐related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma
por: Xiao, Ruoxi, et al.
Publicado: (2022)

Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway
por: Wu, Liwei, et al.
Publicado: (2017)

Chrysin Induces Apoptosis via the MAPK Pathway and Regulates ERK/mTOR-Mediated Autophagy in MC-3 Cells
por: Jung, Gi-Hwan, et al.
Publicado: (2022)

Impact of NPM, TFF3 and TACC1 on the Prognosis of Patients with Primary Gastric Cancer
por: Ding, Aiping, et al.
Publicado: (2013)

Polysaccharide from Angelica sinensis attenuates SNP-induced apoptosis in osteoarthritis chondrocytes by inducing autophagy via the ERK1/2 pathway
por: Xu, Chao, et al.
Publicado: (2021)

Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells
por: Xu, Chunyan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mi20u0namlngesl1adu03qclbi