Rapamycin downregulates NKG2D ligands in acute myeloid leukemia cells via an activation of the STAT3 pathway: a potential mechanism for rapamycin-induced immune escape in leukemia

BACKGROUND: The constitutive activation of the mammalian target of rapamycin (mTOR) is involved in the pathogenesis of many cancers. Rapamycin (RAPA), a specific inhibitor of mTOR, has been applied to the clinical treatment of tumors, and its anti-leukemia effect has also been confirmed. METHODS: We...

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Detalles Bibliográficos
Autores principales: Zhu, Zhichao, Bai, Yu, Lu, Xuzhang, Ding, Jun, Qi, Chunjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798175/
https://www.ncbi.nlm.nih.gov/pubmed/35116779
http://dx.doi.org/10.21037/tcr.2019.03.01

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798175/
https://www.ncbi.nlm.nih.gov/pubmed/35116779
http://dx.doi.org/10.21037/tcr.2019.03.01

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