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Hepatocellular carcinoma serum derived exosomal HIF-1α induces phosphoinositide-3 kinase/protein kinase B signaling to induce the angiogenesis and proliferation of HCC

BACKGROUND: Tumor exosomes are nanovesicles mostly secreted by tumor cells that play roles of paracrine signaling during tumor progression, including tumor-stromal interactions, activation of proliferative pathways and inducing immunosuppression. The hypoxia-inducible factor (HIF) family serve role...

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Detalles Bibliográficos
Autores principales: Xu, Qingyu, You, Ran, Yin, Guowen, Gu, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798372/
https://www.ncbi.nlm.nih.gov/pubmed/35116898
http://dx.doi.org/10.21037/tcr.2019.08.07