Cargando…

Autophagy regulates the cancer stem cell phenotype of head and neck squamous cell carcinoma through the noncanonical FOXO3/SOX2 axis

Autophagy is an essential catabolic process that orchestrates cellular homeostasis and plays dual roles in tumor promotion and suppression. However, the mechanism by which autophagy affects the self-renewal of cancer stem cells (CSCs) remains unclear. In this study, we investigated whether autophagy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yang, Zhao, Hui, Liang, Weilian, Jiang, Erhui, Zhou, Xiaocheng, Shao, Zhe, Liu, Ke, Shang, Zhengjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799462/ https://www.ncbi.nlm.nih.gov/pubmed/34795388 http://dx.doi.org/10.1038/s41388-021-02115-7

Ejemplares similares

Long Noncoding RNAs in the Metastasis of Oral Squamous Cell Carcinoma
por: Xu, Yuming, et al.
Publicado: (2021)

HSP90/IKK‐rich small extracellular vesicles activate pro‐angiogenic melanoma‐associated fibroblasts via the NF‐κB/CXCL1 axis
por: Tang, Hokeung, et al.
Publicado: (2022)

Salivary Porphyromonas gingivalis predicts outcome in oral squamous cell carcinomas: a cohort study
por: Chen, Qingli, et al.
Publicado: (2021)

Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN
por: Liang, Weilian, et al.
Publicado: (2022)

LncRNA FENDRR in Carcinoma-Associated Fibroblasts Regulates the Angiogenesis of Oral Squamous Cell Carcinoma Through the PI3K/AKT Pathway
por: Xu, Yuming, et al.
Publicado: (2021)

Unveiling the Noncanonical Autophagy-Independent Role of ATG7 and ATG9B in Head and Neck Squamous Cell Carcinoma (HNSCC)
por: Guo, Yibo, et al.
Publicado: (2022)

Roles of Mitochondria in Oral Squamous Cell Carcinoma Therapy: Friend or Foe?
por: Bai, Junqiang, et al.
Publicado: (2022)

FOXD1 promotes EMT and cell stemness of oral squamous cell carcinoma by transcriptional activation of SNAI2
por: Chen, Yang, et al.
Publicado: (2021)

SOX2 activation predicts prognosis in patients with head and neck squamous cell carcinoma
por: Chung, Ji Hyun, et al.
Publicado: (2018)

Autophagy-Related Signature for Head and Neck Squamous Cell Carcinoma
por: Li, Cheng, et al.
Publicado: (2020)

Osteosarcoma Cell-Derived Small Extracellular Vesicles Enhance Osteoclastogenesis and Bone Resorption Through Transferring MicroRNA-19a-3p
por: Luo, Tingting, et al.
Publicado: (2021)

Noncanonical HPV carcinogenesis drives radiosensitization of head and neck tumors
por: Schrank, Travis P., et al.
Publicado: (2023)

Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma
por: Lu, Yunping, et al.
Publicado: (2021)

SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma
por: Lee, S H, et al.
Publicado: (2014)

ANXA6/TRPV2 axis promotes lymphatic metastasis in head and neck squamous cell carcinoma by inducing autophagy
por: Wang, Min, et al.
Publicado: (2023)

Noncanonical activation of GLI signaling in SOX2(+) cells drives medulloblastoma relapse
por: Swiderska-Syn, Marzena, et al.
Publicado: (2022)

OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway
por: Wang, Hui, et al.
Publicado: (2020)

Melatonin inhibits EMT and PD‐L1 expression through the ERK1/2/FOSL1 pathway and regulates anti‐tumor immunity in HNSCC
por: Luo, Xinyue, et al.
Publicado: (2022)

Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway
por: Zhou, Xiaocheng, et al.
Publicado: (2018)

Development and Validation of an Autophagy-Related Signature for Head and Neck Squamous Cell Carcinoma
por: Liu, Chang, et al.
Publicado: (2021)

Prognostic Significance of the Pluripotency Factors NANOG, SOX2, and OCT4 in Head and Neck Squamous Cell Carcinomas
por: Pedregal-Mallo, Daniel, et al.
Publicado: (2020)

AFF4 promotes tumorigenesis and tumor-initiation capacity of head and neck squamous cell carcinoma cells by regulating SOX2
por: Deng, Peng, et al.
Publicado: (2018)

Deguelin Induces Both Apoptosis and Autophagy in Cultured Head and Neck Squamous Cell Carcinoma Cells
por: Yang, Yan-li, et al.
Publicado: (2013)

The Hippo effector TAZ promotes cancer stemness by transcriptional activation of SOX2 in head neck squamous cell carcinoma
por: Li, Jin, et al.
Publicado: (2019)

Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma
por: Fernández-Mateos, Javier, et al.
Publicado: (2017)

Identification and validation of autophagy-related prognostic signature for head and neck squamous cell carcinoma
por: Fang, Jiayu, et al.
Publicado: (2021)

Tumor Microenvironment and Cell Fusion
por: Jiang, Erhui, et al.
Publicado: (2019)

miR-762 Promotes Malignant Development of Head and Neck Squamous Cell Carcinoma by Targeting PHLPP2 and FOXO4
por: Chen, Shuai, et al.
Publicado: (2019)

Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma
por: Liu, Zhe, et al.
Publicado: (2020)

C2-Ceramide Induces Cell Death and Protective Autophagy in Head and Neck Squamous Cell Carcinoma Cells
por: Zhu, Wenyuan, et al.
Publicado: (2014)

Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck
por: Jing, Qiancheng, et al.
Publicado: (2019)

Prognostic Correlation of an Autophagy-Related Gene Signature in Patients with Head and Neck Squamous Cell Carcinoma
por: Yang, Cai, et al.
Publicado: (2020)

Nerve Growth Factor (NGF)—Receptor Survival Axis in Head and Neck Squamous Cell Carcinoma
por: Dudás, József, et al.
Publicado: (2018)

Immunotherapy in head and neck squamous cell carcinoma and rare head and neck malignancies
por: Cavalieri, Stefano, et al.
Publicado: (2021)

Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells
por: Hamada, Masakazu, et al.
Publicado: (2017)

NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma
por: Topchu, Iuliia, et al.
Publicado: (2023)

Effect of 3q oncogenes SEC62 and SOX2 on lymphatic metastasis and clinical outcome of head and neck squamous cell carcinomas
por: Bochen, Florian, et al.
Publicado: (2016)

Reciprocal activation of HEY1 and NOTCH4 under SOX2 control promotes EMT in head and neck squamous cell carcinoma
por: Fukusumi, Takahito, et al.
Publicado: (2020)

Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma
por: Ling, Zihang, et al.
Publicado: (2022)

Cutaneous Squamous Cell Carcinoma of the Head and Neck
por: Gurudutt, Vivek V., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_gq8if46a4occhf6cib0nuurl18