Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections

Five New World mammarenaviruses (NWMs) cause life-threatening hemorrhagic fever (HF). Cellular entry by these viruses is mediated by human transferrin receptor 1 (hTfR1). Here, we demonstrate that an antibody (ch128.1/IgG1) which binds the apical domain of hTfR1, potently inhibits infection of atten...

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Detalles Bibliográficos
Autores principales: Hickerson, Brady T., Daniels-Wells, Tracy R., Payes, Cristian, Clark, Lars E., Candelaria, Pierre V., Bailey, Kevin W., Sefing, Eric J., Zink, Samantha, Ziegenbein, James, Abraham, Jonathan, Helguera, Gustavo, Penichet, Manuel L., Gowen, Brian B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799657/
https://www.ncbi.nlm.nih.gov/pubmed/35091550
http://dx.doi.org/10.1038/s41467-021-27949-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799657/
https://www.ncbi.nlm.nih.gov/pubmed/35091550
http://dx.doi.org/10.1038/s41467-021-27949-3

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