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Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytes
Emerging studies suggest that monocytes can be trained by bacterial endotoxin to adopt distinct memory states ranging from low-grade inflammation to immune exhaustion. While low-grade inflammation may contribute to the pathogenesis of chronic diseases, exhausted monocytes with pathogenic and immune-...
Autores principales: | Naler, Lynette B., Hsieh, Yuan-Pang, Geng, Shuo, Zhou, Zirui, Li, Liwu, Lu, Chang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799722/ https://www.ncbi.nlm.nih.gov/pubmed/35091696 http://dx.doi.org/10.1038/s42003-022-03035-2 |
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