Atractylenolide-I covalently binds to CYP11B2, selectively inhibits aldosterone synthesis, and improves hyperaldosteronism

Hyperaldosteronism is a common disease that is closely related to endocrine hypertension and other cardiovascular diseases. Cytochrome P450 11B2 (CYP11B2), an important enzyme in aldosterone (ALD) synthesis, is a promising target for the treatment of hyperaldosteronism. However, selective inhibitors...

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Detalles Bibliográficos
Autores principales: Liu, Wenjuan, Li, Zhenqiang, Chu, Simeng, Ma, Xiaoyao, Wang, Xiaoying, Jiang, Min, Bai, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799885/
https://www.ncbi.nlm.nih.gov/pubmed/35127376
http://dx.doi.org/10.1016/j.apsb.2021.09.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799885/
https://www.ncbi.nlm.nih.gov/pubmed/35127376
http://dx.doi.org/10.1016/j.apsb.2021.09.013

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