Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme

The aerobic energetic metabolism of eukaryotic cells relies on the glycolytic generation of pyruvate, which is subsequently channelled to the oxidative phosphorylation taking place in mitochondria. However, under conditions limiting oxidative phosphorylation, pyruvate is coupled to alternative energ...

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Detalles Bibliográficos
Autores principales: Pasti, Alberto Pietro, Rossi, Valentina, Di Stefano, Giuseppina, Brigotti, Maurizio, Hochkoeppler, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Bioenergetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799922/
https://www.ncbi.nlm.nih.gov/pubmed/35048959
http://dx.doi.org/10.1042/BSR20212654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799922/
https://www.ncbi.nlm.nih.gov/pubmed/35048959
http://dx.doi.org/10.1042/BSR20212654

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