Discovery of novel selective PI3Kγ inhibitors through combining machine learning-based virtual screening with multiple protein structures and bio-evaluation

INTRODUCTION: Phosphoinositide 3-kinase gamma (PI3Kγ) has been regarded as a promising drug target for the treatment of various diseases, and the diverse physiological roles of class I PI3K isoforms (α, β, δ, and γ) highlight the importance of isoform selectivity in the development of PI3Kγ inhibito...

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Detalles Bibliográficos
Autores principales: Zhu, Jingyu, Li, Kan, Xu, Lei, Cai, Yanfei, Chen, Yun, Zhao, Xinling, Li, Huazhong, Huang, Gang, Jin, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Basic and Biological Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800018/
https://www.ncbi.nlm.nih.gov/pubmed/35127160
http://dx.doi.org/10.1016/j.jare.2021.04.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800018/
https://www.ncbi.nlm.nih.gov/pubmed/35127160
http://dx.doi.org/10.1016/j.jare.2021.04.007

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