Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors

Recent clinical studies report that chromosomal 12q24.31 microdeletions are associated with autism spectrum disorder (ASD) and intellectual disability (ID). However, the causality and underlying mechanisms linking 12q24.31 microdeletions to ASD/ID remain undetermined. Here we show Kdm2b, one gene lo...

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Detalles Bibliográficos
Autores principales: Gao, Yuen, Duque-Wilckens, Natalia, Aljazi, Mohammad B., Moeser, Adam J., Mias, George I., Robison, Alfred J., Zhang, Yi, He, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800019/
https://www.ncbi.nlm.nih.gov/pubmed/35128353
http://dx.doi.org/10.1016/j.isci.2022.103742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800019/
https://www.ncbi.nlm.nih.gov/pubmed/35128353
http://dx.doi.org/10.1016/j.isci.2022.103742

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