The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells

Pancreatic adenocarcinoma (PAAD) is one of the most lethal malignancies. Although gemcitabine (GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C (Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not...

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Detalles Bibliográficos
Autores principales: Wang, Junxia, Chen, Minghua, Wang, Mengyan, Zhao, Wenxia, Zhang, Conghui, Liu, Xiujun, Cai, Meilian, Qiu, Yuhan, Zhang, Tianshu, Zhou, Huimin, Zhao, Wuli, Si, Shuyi, Shao, Rongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800039/
https://www.ncbi.nlm.nih.gov/pubmed/35127381
http://dx.doi.org/10.1016/j.apsb.2021.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800039/
https://www.ncbi.nlm.nih.gov/pubmed/35127381
http://dx.doi.org/10.1016/j.apsb.2021.07.004

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