Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1α-mediated transcriptional regulation of their transporters

Hypoxia exerts profound effects on cell physiology, but its effect on colonic uptake of the microbiota-generated forms of vitamin B1 (i.e., thiamin pyrophosphate [TPP] and free thiamine) has not been described. Here, we used human colonic epithelial NCM460 cells and human differentiated colonoid mon...

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Detalles Bibliográficos
Autores principales: Sabui, Subrata, Ramamoorthy, Kalidas, Romero, Jose M., Simoes, Rita D., Fleckenstein, James M., Said, Hamid M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800108/
https://www.ncbi.nlm.nih.gov/pubmed/34998824
http://dx.doi.org/10.1016/j.jbc.2022.101562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800108/
https://www.ncbi.nlm.nih.gov/pubmed/34998824
http://dx.doi.org/10.1016/j.jbc.2022.101562

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