Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties

Alpha-synuclein (aSyn) is a vertebrate protein, normally found within the presynaptic nerve terminal and nucleus, which is known to form somatic and neuritic aggregates in certain neurodegenerative diseases. Disease-associated aggregates of aSyn are heavily phosphorylated at serine-129 (pSyn), while...

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Detalles Bibliográficos
Autores principales: Dent, Sydney E., King, Dennisha P., Osterberg, Valerie R., Adams, Eleanor K., Mackiewicz, Marilyn R., Weissman, Tamily A., Unni, Vivek K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800120/
https://www.ncbi.nlm.nih.gov/pubmed/34973339
http://dx.doi.org/10.1016/j.jbc.2021.101552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800120/
https://www.ncbi.nlm.nih.gov/pubmed/34973339
http://dx.doi.org/10.1016/j.jbc.2021.101552

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