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MORPHIOUS: an unsupervised machine learning workflow to detect the activation of microglia and astrocytes

BACKGROUND: In conditions of brain injury and degeneration, defining microglial and astrocytic activation using cellular markers alone remains a challenging task. We developed the MORPHIOUS software package, an unsupervised machine learning workflow which can learn the morphologies of non-activated...

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Detalles Bibliográficos
Autores principales: Silburt, Joseph, Aubert, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800241/
https://www.ncbi.nlm.nih.gov/pubmed/35093113
http://dx.doi.org/10.1186/s12974-021-02376-9