Cargando…

The ILEI/LIFR complex induces EMT via the Akt and ERK pathways in renal interstitial fibrosis

BACKGROUND: Chronic kidney disease (CKD) is characterized by high morbidity and mortality and is difficult to cure. Renal interstitial fibrosis (RIF) is a major determinant of, and commonly occurs within, CKD progression. Epithelial mesenchymal transition (EMT) has been identified as a crucial proce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jieqing, Jiang, Hong, Jiang, Hongkun, Fan, Yan, Zhang, Jing, Ma, Xiaoxue, Yang, Xuewei, Sun, Yu, Zhao, Xing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800269/ https://www.ncbi.nlm.nih.gov/pubmed/35093095 http://dx.doi.org/10.1186/s12967-022-03265-2

Ejemplares similares

TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis
por: Woosley, Alec N., et al.
Publicado: (2019)

Unusual Form of Diverticulum Ilei
por: Struthers, J. W.
Publicado: (1911)

Stricture Ilei, Laparo-enterotomy
por: Mynter, Herman
Publicado: (1880)

Melanosis ilei induced by prolonged charcoal ingestion
por: Kim, Gun Min, et al.
Publicado: (2011)

Diverticulum Ilei (Meckel) within the Layers of the Mesentery
por: Struthers, J. W.
Publicado: (1930)

Melanosis Ilei Associated with Chronic Ingestion of Oral Iron
por: Cha, Jae Myung, et al.
Publicado: (2009)

Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1)
por: Noguchi, Ken, et al.
Publicado: (2018)

The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness
por: Schmidt, Ulrike, et al.
Publicado: (2021)

Targeting LIF/LIFR signaling in cancer
por: Viswanadhapalli, Suryavathi, et al.
Publicado: (2021)

Transforming Growth Factor-β (TGFβ)-mediated Phosphorylation of hnRNP E1 Induces EMT via Transcript Selective Translational Induction of Dab2 and ILEI
por: Chaudhury, Arindam, et al.
Publicado: (2010)

Anlotinib Alleviates Renal Fibrosis via Inhibition of the ERK and AKT Signaling Pathways
por: Sun, Donglin, et al.
Publicado: (2023)

In Vitro and In Vivo Antifibrotic Effects of Fraxetin on Renal Interstitial Fibrosis via the ERK Signaling Pathway
por: Hsieh, Yi-Hsien, et al.
Publicado: (2021)

Inducible overexpression of a FAM3C/ILEI transgene has pleiotropic effects with shortened life span, liver fibrosis and anemia in mice
por: Schmidt, Ulrike, et al.
Publicado: (2023)

FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice
por: Malik, Barizah, et al.
Publicado: (2023)

Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF‐α‐Smurf1‐Akt‐mTOR‐P70S6K pathway
por: Zhou, Jiajun, et al.
Publicado: (2019)

FGFR3 promotes the growth and malignancy of melanoma by influencing EMT and the phosphorylation of ERK, AKT, and EGFR
por: Li, Lei, et al.
Publicado: (2019)

Stüve-Wiedemann syndrome: LIFR and associated cytokines in clinical course and etiology
por: Mikelonis, Dawn, et al.
Publicado: (2014)

Inhibition of LIFR Blocks Adiposity-Driven Endometrioid Endometrial Cancer Growth
por: Blankenship, Logan, et al.
Publicado: (2022)

Circular RNA circARPP21 Acts as a Sponge of miR-543 to Suppress Hepatocellular Carcinoma by Regulating LIFR
por: Gu, Yichao, et al.
Publicado: (2021)

Renal Interstitial Fibrosis and Angiotensin Inhibition
por: Koo, Ja Wook
Publicado: (2006)

Aldosterone promotes renal interstitial fibrosis via the AIF-1/AKT/mTOR signaling pathway
por: Yuan, Xueying, et al.
Publicado: (2019)

LIF/LIFR oncogenic signaling is a novel therapeutic target in endometrial cancer
por: Tang, Weiwei, et al.
Publicado: (2021)

Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers
por: Bai, Zhiqun, et al.
Publicado: (2022)

LncRNA LIFR‐AS1 overexpression suppressed the progression of serous ovarian carcinoma
por: Liu, Fang, et al.
Publicado: (2022)

Downregulation of circLIFR exerts cancer-promoting effects on hepatocellular carcinoma in vitro
por: Ji, Jingzhang, et al.
Publicado: (2022)

miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop
por: Zhang, Feifei, et al.
Publicado: (2018)

Livin participates in resistance to trastuzumab therapy for breast cancer through ERK1/2 and AKT pathways and promotes EMT-like phenotype
por: Li, Fan, et al.
Publicado: (2018)

Long non-coding RNA lnc-CHAF1B-3 promotes renal interstitial fibrosis by regulating EMT-related genes in renal proximal tubular cells
por: Imai, Kentaro, et al.
Publicado: (2022)

ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway
por: Xu, Jinming, et al.
Publicado: (2023)

High LIFr expression stimulates melanoma cell migration and is associated with unfavorable prognosis in melanoma
por: Guo, Hongwei, et al.
Publicado: (2015)

LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer
por: Li, Mengxing, et al.
Publicado: (2021)

HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer
por: Clements, Miranda E., et al.
Publicado: (2021)

The LIFR-targeting small molecules EC330/EC359 are potent ferroptosis inducers
por: Feng, Chang-Zhou, et al.
Publicado: (2022)

CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSα/ATM-p73 axis in bladder cancer
por: Zhang, Hui, et al.
Publicado: (2021)

Acupuncture attenuates renal interstitial fibrosis via the TGF-β/Smad pathway
por: Zuo, Zheng, et al.
Publicado: (2019)

Synovial tissue quantitative proteomics analysis reveals paeoniflorin decreases LIFR and ASPN proteins in experimental rheumatoid arthritis
por: Yang, Shu, et al.
Publicado: (2018)

SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease
por: Li, Xiaoxue, et al.
Publicado: (2022)

MiR-21 Simultaneously Regulates ERK1 Signaling in HSC Activation and Hepatocyte EMT in Hepatic Fibrosis
por: Zhao, Juan, et al.
Publicado: (2014)

Induced Autologous Stem Cell Transplantation for Treatment of Rabbit Renal Interstitial Fibrosis
por: Ruan, Guang-Ping, et al.
Publicado: (2013)

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow
por: Johnson, Rachelle W., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l816rha0um706ed65ko90a3l18