Cargando…

Single-cell transcriptomic analysis reveals a novel cell state and switching genes during hepatic stellate cell activation in vitro

BACKGROUND: The transformation of hepatic stellate cell (HSC) to myofibroblast is a key event during liver fibrogenesis. However, the differentiation trajectory of HSC-to-myofibroblast transition and the switching genes during this process remains not well understood. METHODS: We applied single-cell...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Hua, Zheng, Shaoping, Jiang, Hongbo, Wang, Xuejia, Zhou, Fengqin, Weng, Zhihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8800312/ https://www.ncbi.nlm.nih.gov/pubmed/35093101 http://dx.doi.org/10.1186/s12967-022-03263-4

Ejemplares similares

Single‐Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell–Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice
por: Yang, Wu, et al.
Publicado: (2021)

Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity
por: Payen, Valéry L., et al.
Publicado: (2021)

In vitro reversion of activated primary human hepatic stellate cells
por: El Taghdouini, Adil, et al.
Publicado: (2015)

Hepatic Stellate Cells and Hepatocarcinogenesis
por: Barry, Anna E., et al.
Publicado: (2020)

Intercellular Adhesive Structures Between Stellate Cells – An Analysis in Cultured Human Hepatic Stellate Cells
por: Imai, Katsuyuki, et al.
Publicado: (2004)

Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
por: Herrmann, Jens, et al.
Publicado: (2007)

Heterogeneity of Hepatic Stellate Cells in Fibrogenesis of the Liver: Insights from Single-Cell Transcriptomic Analysis in Liver Injury
por: Zhang, Wenjun, et al.
Publicado: (2021)

Low concentrations of bilirubin inhibit activation of hepatic stellate cells in vitro
por: Tang, Yinhe, et al.
Publicado: (2017)

The Transcriptomic Response of Rat Hepatic Stellate Cells to Endotoxin: Implications for Hepatic Inflammation and Immune Regulation
por: Harvey, Stephen A. K., et al.
Publicado: (2013)

In vivo and in vitro Interactions between Human Colon Carcinoma Cells and Hepatic Stellate Cells
por: Shimizu, Sadatoshi, et al.
Publicado: (2000)

PPAR Gamma and Hepatic Stellate Cells
por: Hazra, Saswati, et al.
Publicado: (2004)

Single-cell transcriptomics of hepatic stellate cells uncover crucial pathways and key regulators involved in non-alcoholic steatohepatitis
por: He, Weiwei, et al.
Publicado: (2022)

MicroRNA-195 Activates Hepatic Stellate Cells In Vitro by Targeting Smad7
por: Song, Li-Ying, et al.
Publicado: (2017)

Hepatic stellate cells: central modulators of hepatic carcinogenesis
por: Thompson, Alexandra I, et al.
Publicado: (2015)

Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis
por: Zhao, Yuan-Quan, et al.
Publicado: (2023)

Human umbilical cord mesenchymal stem cells inhibit proliferation of hepatic stellate cells in vitro
por: Zhang, Li-Ting, et al.
Publicado: (2018)

Insights into the impact of hepatitis B virus on hepatic stellate cell activation
por: You, Hongjuan, et al.
Publicado: (2023)

Integrated network analysis of transcriptomic and protein-protein interaction data in taurine-treated hepatic stellate cells
por: Liang, Xing-Qiu, et al.
Publicado: (2019)

Crosstalk between NK cells and hepatic stellate cells in liver fibrosis
por: Zhang, Yang, et al.
Publicado: (2022)

The Effects of Old Age on Hepatic Stellate Cells
por: Warren, Alessandra, et al.
Publicado: (2011)

Irisin Regulates the Functions of Hepatic Stellate Cells
por: Dong, Hanh Nguyen, et al.
Publicado: (2020)

Proteomic Changes of Activated Hepatic Stellate Cells
por: Schinagl, Maximilian, et al.
Publicado: (2021)

Hepatic Stellate Cell-Immune Interactions in NASH
por: Carter, James K., et al.
Publicado: (2022)

Generation of functionally competent hepatic stellate cells from human stem cells to model liver fibrosis in vitro
por: Lai, Xinyuan, et al.
Publicado: (2022)

Characterization of human stem cell-derived hepatic stellate cells and liver sinusoidal endothelial cells during extended in vitro culture
por: Wilhelmsen, Ingrid, et al.
Publicado: (2023)

Single‐cell RNA sequencing reveals the heterogeneity and intercellular communication of hepatic stellate cells and macrophages during liver fibrosis
por: Cheng, Sheng, et al.
Publicado: (2023)

Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis
por: Schon, Hans-Theo, et al.
Publicado: (2016)

Cancer Stem Cell and Hepatic Stellate Cells in Hepatocellular Carcinoma
por: Quiroz Reyes, Adriana G., et al.
Publicado: (2023)

Tetramethylpyrazine Inhibits Activation of Hepatic Stellate Cells through Hedgehog Signaling Pathways In Vitro
por: Hu, Jue, et al.
Publicado: (2015)

Antifibrotic effects of gallic acid on hepatic stellate cells: In vitro and in vivo mechanistic study
por: El-Lakkany, Naglaa M., et al.
Publicado: (2018)

Genetic Characterization of Rat Hepatic Stellate Cell Line HSC-T6 for In Vitro Cell Line Authentication
por: Nanda, Indrajit, et al.
Publicado: (2022)

Crosstalk between hepatic stellate cells and tumor cells in the development of hepatocellular carcinoma
por: Ma, Ya-Nan, et al.
Publicado: (2021)

Single cell analysis in native tissue: Quantification of the retinoid content of hepatic stellate cells
por: Galler, Kerstin, et al.
Publicado: (2016)

The role of hepatic stellate cells in the regulation of T-cell function and the promotion of hepatocellular carcinoma
por: ZHAO, WENXIU, et al.
Publicado: (2012)

Agrin para-secreted by PDGF-activated human hepatic stellate cells promotes hepatocarcinogenesis in vitro and in vivo
por: Lv, Xing, et al.
Publicado: (2017)

Mitochondrial uncouplers inhibit hepatic stellate cell activation
por: Guimarães, Eduardo L, et al.
Publicado: (2012)

Hepatic stellate cells and parasite-induced liver fibrosis
por: Anthony, Barrie, et al.
Publicado: (2010)

Epigenetic regulation during hepatic stellate cell activation
por: Götze, Silke, et al.
Publicado: (2014)

Epigenetic Changes during Hepatic Stellate Cell Activation
por: Götze, Silke, et al.
Publicado: (2015)

Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
por: Hou, Wei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vnacjm63mba0d8tc2ito62cfo2