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Whole exome sequencing identified a rare WT1 loss‐of‐function variant in a non‐syndromic POI patient
BACKGROUND: Premature ovarian insufficiency (POI) is a highly heterogeneous disease, and up to 25% of cases can be explained by genetic causes. The transcription factor WT1 has long been reported to play a crucial role in ovary function. Wt1‐mutated female mice exhibited POI‐like phenotypes. METHODS...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801142/ https://www.ncbi.nlm.nih.gov/pubmed/34845858 http://dx.doi.org/10.1002/mgg3.1820 |