Enhanced neutrophil extracellular trap formation in COVID-19 is inhibited by the protein kinase C inhibitor ruboxistaurin

BACKGROUND: Neutrophil extracellular traps (NETs) are web-like DNA and protein lattices which are expelled by neutrophils to trap and kill pathogens, but which cause significant damage to the host tissue. NETs have emerged as critical mediators of lung damage, inflammation and thrombosis in coronavi...

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Detalles Bibliográficos
Autores principales: Dowey, Rebecca, Cole, Joby, Thompson, A.A. Roger, Hull, Rebecca C., Huang, Chenghao, Whatmore, Jacob, Iqbal, Ahmed, Bradley, Kirsty L., McKenzie, Joanne, Lawrie, Allan, Condliffe, Alison M., Kiss-Toth, Endre, Sabroe, Ian, Prince, Lynne R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801155/
https://www.ncbi.nlm.nih.gov/pubmed/35382002
http://dx.doi.org/10.1183/23120541.00596-2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801155/
https://www.ncbi.nlm.nih.gov/pubmed/35382002
http://dx.doi.org/10.1183/23120541.00596-2021

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