PERK prevents hepatic lipotoxicity by activating the p62-ULK1 axis-mediated noncanonical KEAP1-Nrf2 pathway

Hepatic lipotoxicity is a crucial factor in nonalcoholic steatohepatitis resulting from excessive saturated fatty acid-induced reactive oxygen species (ROS)-mediated cell death, which is associated with the accumulation of endoplasmic reticulum (ER) stress in the liver. The unfolded protein response...

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Detalles Bibliográficos
Autores principales: Lee, Da Hyun, Park, Jeong Su, Lee, Yu Seol, Bae, Soo Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801383/
https://www.ncbi.nlm.nih.gov/pubmed/35091323
http://dx.doi.org/10.1016/j.redox.2022.102235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801383/
https://www.ncbi.nlm.nih.gov/pubmed/35091323
http://dx.doi.org/10.1016/j.redox.2022.102235

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