PARP-1 regulates inflammasome activity by poly-ADP-ribosylation of NLRP3 and interaction with TXNIP in primary macrophages

Poly(ADP-ribose) polymerase-1 (PARP-1) plays an essential role in DNA repair by catalyzing the polymerization of ADP-ribose unit to target proteins. Several studies have shown that PARP-1 can regulate inflammatory responses in various disease models. The intracellular Nod-like receptor NLRP3 has eme...

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Detalles Bibliográficos
Autores principales: Chiu, Ling-Ya, Huang, Duen-Yi, Lin, Wan-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801414/
https://www.ncbi.nlm.nih.gov/pubmed/35098371
http://dx.doi.org/10.1007/s00018-022-04138-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801414/
https://www.ncbi.nlm.nih.gov/pubmed/35098371
http://dx.doi.org/10.1007/s00018-022-04138-z

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