Influence of T Cell-Mediated Immune Surveillance on Somatic Mutation Occurrences in Melanoma

BACKGROUND: Neoantigens are presented on the cancer cell surface by peptide-restricted human leukocyte antigen (HLA) proteins and can subsequently activate cognate T cells. It has been hypothesized that the observed somatic mutations in tumors are shaped by immunosurveillance. METHODS: We investigat...

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Detalles Bibliográficos
Autores principales: Jiang, Chongming, Schaafsma, Evelien, Hong, Wei, Zhao, Yanding, Zhu, Ken, Chao, Cheng-Chi, Cheng, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801458/
https://www.ncbi.nlm.nih.gov/pubmed/35111147
http://dx.doi.org/10.3389/fimmu.2021.703821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801458/
https://www.ncbi.nlm.nih.gov/pubmed/35111147
http://dx.doi.org/10.3389/fimmu.2021.703821

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