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Influence of T Cell-Mediated Immune Surveillance on Somatic Mutation Occurrences in Melanoma
BACKGROUND: Neoantigens are presented on the cancer cell surface by peptide-restricted human leukocyte antigen (HLA) proteins and can subsequently activate cognate T cells. It has been hypothesized that the observed somatic mutations in tumors are shaped by immunosurveillance. METHODS: We investigat...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801458/ https://www.ncbi.nlm.nih.gov/pubmed/35111147 http://dx.doi.org/10.3389/fimmu.2021.703821 |