Cargando…

Neuroprotective Effects of a Small Mitochondrially-Targeted Tetrapeptide Elamipretide in Neurodegeneration

Neural mitochondrial dysfunction, neural oxidative stress, chronic neuroinflammation, toxic protein accumulation, and neural apoptosis are common causes of neurodegeneration. Elamipretide, a small mitochondrially-targeted tetrapeptide, exhibits therapeutic effects and safety in several mitochondria-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nhu, Nguyen Thanh, Xiao, Shu-Yun, Liu, Yijie, Kumar, V. Bharath, Cui, Zhen-Yang, Lee, Shin-Da
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Integrative Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801496/ https://www.ncbi.nlm.nih.gov/pubmed/35111001 http://dx.doi.org/10.3389/fnint.2021.747901

Ejemplares similares

Effects of Mdivi-1 on Neural Mitochondrial Dysfunction and Mitochondria-Mediated Apoptosis in Ischemia-Reperfusion Injury After Stroke: A Systematic Review of Preclinical Studies
por: Nhu, Nguyen Thanh, et al.
Publicado: (2021)

Elamipretide (SS-31) Ameliorates Isoflurane-Induced Long-Term Impairments of Mitochondrial Morphogenesis and Cognition in Developing Rats
por: Wu, Jing, et al.
Publicado: (2017)

Elamipretide Improves Mitochondrial Function in the Failing Human Heart
por: Chatfield, Kathryn C., et al.
Publicado: (2019)

Elamipretide Attenuates Pyroptosis and Perioperative Neurocognitive Disorders in Aged Mice
por: Zuo, Youmei, et al.
Publicado: (2020)

Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration
por: Mahalakshmi, B., et al.
Publicado: (2020)

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy
por: Karaa, Amel, et al.
Publicado: (2018)

A randomized crossover trial of elamipretide in adults with primary mitochondrial myopathy
por: Karaa, Amel, et al.
Publicado: (2020)

Editorial: Neurodegeneration and Neuroprotection in Retinal Disease, Volume II
por: Casini, Giovanni, et al.
Publicado: (2022)

Barth syndrome cardiomyopathy: targeting the mitochondria with elamipretide
por: Sabbah, Hani N.
Publicado: (2020)

Abnormalities of Mitochondrial Dynamics in the Failing Heart: Normalization Following Long-Term Therapy with Elamipretide
por: Sabbah, Hani N., et al.
Publicado: (2018)

Triphenylphosphonium Moiety Modulates Proteolytic Stability and Potentiates Neuroprotective Activity of Antioxidant Tetrapeptides in Vitro
por: Akhmadishina, Rezeda A., et al.
Publicado: (2018)

Editorial: Brain Hypoxia and Ischemia: New Insights Into Neurodegeneration and Neuroprotection
por: Nalivaeva, Natalia N., et al.
Publicado: (2019)

Editorial: Mitochondrial Dysfunction and Neurodegeneration
por: Tapias, Victor
Publicado: (2019)

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice
por: Zhao, Weixing, et al.
Publicado: (2019)

Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial
por: Karaa, Amel, et al.
Publicado: (2023)

Elamipretide (SS-31) Improves Functional Connectivity in Hippocampus and Other Related Regions Following Prolonged Neuroinflammation Induced by Lipopolysaccharide in Aged Rats
por: Liu, Yang, et al.
Publicado: (2021)

Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration
por: Saragovi, Horacio Uri, et al.
Publicado: (2019)

Directed Discovery of Tetrapeptide Emulsifiers
por: Scott, Gary G., et al.
Publicado: (2022)

The effects of a mitochondrial targeted peptide (elamipretide/SS31) on BAX recruitment and activation during apoptosis
por: Grosser, Joshua A., et al.
Publicado: (2021)

Editorial: Central nervous system acting drugs-molecular mechanisms of neuroprotection and neurodegeneration
por: El Sayed, Nesrine S., et al.
Publicado: (2022)

Editorial: Brain hypoxia and ischemia: New insights into neurodegeneration and neuroprotection, volume II
por: Nalivaeva, Natalia N., et al.
Publicado: (2023)

Effects of Elamipretide on Autophagy in Renal Cells of Pigs with Metabolic Syndrome
por: Hong, Siting, et al.
Publicado: (2022)

Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice
por: Campbell, Matthew D., et al.
Publicado: (2022)

Effect of exercise training on cardiac mitochondrial respiration, biogenesis, dynamics, and mitophagy in ischemic heart disease
por: Viloria, Mary Audrey D., et al.
Publicado: (2022)

Combined Neuroprotective Strategies Blocked Neurodegeneration and Improved Brain Function in Senescence-Accelerated Mice
por: Malerba, Helena Nascimento, et al.
Publicado: (2021)

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction
por: Zorzano, Antonio, et al.
Publicado: (2015)

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration
por: Pérez, María J., et al.
Publicado: (2018)

Small Vessels Are a Big Problem in Neurodegeneration and Neuroprotection
por: Erdener, Şefik Evren, et al.
Publicado: (2019)

Effects of elamipretide on skeletal muscle in dogs with experimentally induced heart failure
por: Sabbah, Hani N., et al.
Publicado: (2019)

New Retinal Pigment Epithelial Cell Model to Unravel Neuroprotection Sensors of Neurodegeneration in Retinal Disease
por: Asatryan, Aram, et al.
Publicado: (2022)

Neurodegeneration and Neuroprotection in Glaucoma
por: Gauthier, Angela C., et al.
Publicado: (2016)

High levels of Bifidobacteriaceae are associated with the pathogenesis of Parkinson’s disease
por: Zuo, ShuJia, et al.
Publicado: (2023)

Brain Mitochondrial Dysfunction in Aging, Neurodegeneration, and Parkinson's Disease
por: Navarro, Ana, et al.
Publicado: (2010)

Dichloroacetate Stabilizes Mitochondrial Fusion Dynamics in Models of Neurodegeneration
por: O’Hara, Darren, et al.
Publicado: (2019)

Dietary Alterations in Impaired Mitochondrial Dynamics Due to Neurodegeneration
por: Ashraf, Ghulam Md, et al.
Publicado: (2022)

Mitochondrial Preconditioning: A Potential Neuroprotective Strategy
por: Correia, Sónia C., et al.
Publicado: (2010)

Anti-tumour effect of the physiological tetrapeptide, tuftsin.
por: Nishioka, K.
Publicado: (1979)

Fibronectin tetrapeptide is target for syphilis spirochete cytadherence
Publicado: (1985)

Elamipretide for Barth syndrome cardiomyopathy: gradual rebuilding of a failed power grid
por: Sabbah, Hani N.
Publicado: (2021)

Natural history comparison study to assess the efficacy of elamipretide in patients with Barth syndrome
por: Hornby, Brittany, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sqht7k6di3rhls4jl0056ig5mc